Steps to reproduce the issue

Login to Joomla 4 admin as your super admin and edit yourself in Users -> Manage

administrator/index.php?option=com_users&view=users

Note that everything fits within the browser viewport.

Enable Increase Font Size
Enable Highlight Links
(ok for giggles enable Monochrome and High Contrast too, but you can replicate without those enabled)
Save

You are now back at the Users list administrator/index.php?option=com_users&view=users

Note now that the table of users doesn't fit on the screen whereas it used to (it has some content off the screen to the right)

Also note that ALL OTHER COMPONENTS correctly fit within the browser width - its only the list of users in com_users that doest.

Eg:

Expected result

Enabling accessibility features should not make the page wider so that it floats outside the browser viewport, it should wrap in squeeze in, or do what the other views are doing correctly.

Actual result

As explained above

System information (as much as possible)

Safari on mac

Additional comments